Name: Recombinant Human ACE2 His and FLAG Tag (HEK293 cells)
Price: Inquiry

- Overview
  - Angiotensin-converting enzyme 2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is the cause of COVID-19.
    
    Please contact us at for specific academic pricing.
- Properties
  - Source
    
    HEK293 cells
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    >95% by SDS-PAGE.
    
    Formulation
    
    0.5 mg/ml in sterile PBS with 20% Glycerol, pH 7.4
    
    Storage
    
    Recombinant Human ACE2 His Tag protein is shipped on ice packs. Upon arrival, Store at -20°C. Do not freeze-thaw multiple times.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.
- Applications
  - Application
    
    Functional Assay; ELISA; WB

SDS-PAGE analysis of purified Recombinant Human ACE2 His Tag Protein. 2 µg protein was run on a 4-20% SDS-PAGE gel followed by Coomassie blue staining.

Recombinant Human ACE2 His and FLAG Tag (HEK293 cells)

Recombinant Human ACE2 His and FLAG Tag (HEK293 cells)

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