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Overview
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RNA-splicing ligase RtcB is a member of RtcB family. It is a GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. RtcB rejoins broken stem-loops of tRNA with 2,3-cyclic-phosphate or 3-phosphate ends to RNA with 5-hydroxy ends. RtcB can also act as a DNA ligase in case of DNA damage by splicing dirty DNA breaks, characterized by 3-phosphate (or cyclic-phosphate) and 5-hydroxy ends that cannot be sealed by classical DNA ligases.
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Overview
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