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Recombinant Cynomolgus Programmed cell death 1/PDCD1(C-Fc)

Recombinant Cynomolgus Programmed cell death 1/PDCD1(C-Fc)

Catalog Number:
P001410832ABE
Mfr. No.:
Abe32-9353
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      • Overview

        • Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-gamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.

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      • Properties
        • Protein Name
          Programmed cell death 1; PD-1; PD1
          Source
          Human cells
          Type
          Recombinant Proteins
          Formulation
          Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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