Rabbit anti-ERBB2 Polyclonal Antibody

Rabbit anti-ERBB2 Polyclonal Antibody

Catalog Number:
A001080254RED
Mfr. No.:
RD70397A
Price:
$347
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      • Overview
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          Background

          HER2,also known as ErbB2 and Neu,is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However,it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer,stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways,such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers,including
          breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas.

      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human
          Immunogen
          KLH conjugated Synthetic peptide corresponding to Mouse ErbB2
          Purification
          Affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.
          Storage
          Store at -20°C. Avoid repeated freeze / thaw cycles.
          Concentration
          1.3 mg/mL
          Antigen
          Verb b2 erythroblastic leukemia viral oncogene homolog 2; neuro/glioblastoma derived oncogene homolog; C erb B2/neu protein; CD340; CD340 antigen; Cerb B2/neu protein; CerbB2; Erb b2 receptor tyrosine kinase 2; ERBB2; ERBB2; HER 2; HER 2/NEU; HER2; Herstatin; Human epidermal growth factor receptor 2; Metastatic lymph node gene 19 protein; MLN 19; MLN19; NEU; NEU proto oncogene; Neuro/glioblastoma derived oncogene homolog; Neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase type cell surface receptor HER2; Tyrosine kinase-type cell surface receptor HER2; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); V erb b2 avian erythroblastic leukemia viral oncogene homolog 2; V erb b2 avian erythroblastic leukemia viral oncoprotein 2; V erb b2 erythroblastic leukemia viral oncogene homolog 2; neuro/glioblastoma derived oncogene homolog (avian); V erb b2 erythroblastic leukemia viral oncogene homolog 2; neuro/glioblastoma derived oncogene homolog; Verb b2 erythroblastic leukemia viral oncogene homolog 2; neuro/glioblastoma derived oncogene homolog (avian) (UniProt:P04626, P70424)

          * For research use only.

      • Applications
        • Application
          WB

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