Name: Quinidine
Price: 188.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Quinidine is a clinical antiarrhythmic drug, which is used to treat abnormal heart rhythms and malaria[1].
    The application of quinidine in the bath results in a dose-dependent decrease in the peak amplitude of Ik. Kd for Ik block at 0 mV is estimated to be 41 μM[1].
    In rats, quinidine inhibits metabolism of amphetamine. Quinidine pretreatment significantly reduces excretion of p-hydroxyamphetamine at 24 and 48 hours, to 7.2% and 24.1% of vehicle control levels, and significantly increases excretion of amphetamine between 24 and 48 hours to 542%[2].
    
    Reference:
    [1]. Kehl S J, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol, 1991, 103(3): 1807-13.
    [2]. Moody D E, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol, 1990, 14(5): 311-7.
- Properties
  - Categories
    
    reduces both Na+ and K+ channel currents
    
    Alternative Name
    
    (R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5S)-5-vinylquinuclidin-2-yl)methanol
    
    CAS Number
    
    56-54-2
    
    Molecular Formula
    
    C20H24N2O2
    
    Molecular Weight
    
    324.42
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥10.32 mg/mL in EtOH with ultrasonic; ≥11.95 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O[[email protected]](C(C1=C2)=CC=NC1=CC=C2OC)[[email protected]@H]3[[email protected]@]4C[[email protected]@H](C=C)[[email protected]@H](CC4)C3
    
    * For Research Use Only