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Overview
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CD154 (CD40 Ligand, gp39) is an accessory molecule expressed on activated T helper (CD4+) lymph ocytes. CD154 has also been detected on other types of leukocytes, including CD8+ T cells, medullary thymocytes, activated CD4+ NK-T cells, and human NK cells. CD154 plays an important role in costimulatory interactions between T and B lymph ocytes and between antigen-presenting cells and lymph ocytes, regulating the immune response at multiple levels. MR1 mAb inhibits in vitro activation of B lymph ocytes by T helper cells by blocking interaction of gp39 with CD40. In vitro interactions of T cells and antigen-presenting cells can also be blocked by the MR1 antibody. In vivo treatment with MR1 antibody blocks the development of experimental autoimmune disease, inhibits formation of germinal centers and generation of memory B cells, reduces T-lymph ocyte responses to allogeneic cells and allografts, prevents intrathymic deletion of self-reactive T lymph ocytes, and disrupts antigen-specific T-cell responses.
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