Name: PURE - anti Human CD49d - ALC1/1
Price: 361.00 USD

- Overview
  - This antibody reacts with the CD49d antigen, which recognizes the 150-kilodalton (kd) α-chain of very-late antigen (VLA)-4, a member of the integrin family of cell adhesion molecules. VLA-4, like other integrins, is a noncovalently associated heterodimeric glycoprotein composed of α and ß subunits and is involved in cell–cell and cell–extracellular matrix interactions. The ß-chain of the VLA-4 complex is the CD29 antigen, a 130-kd glycoprotein. The CD29 antigen, also known as the ß-1 subunit, is common to the VLA family of integrins. When acting as a matrix receptor, the CD49d antigen binds to CS-1, an alternatively spliced domain of fibronectin. When functioning as a cell receptor, the CD49d antigen binds to the vascular cell-adhesion molecule-1 (VCAM-1). The interaction between the CD49d antigen and VCAM-1 is known to play an important role in stabilizing the adhesion of lymphocytes to endothelial cells and in mediating B-lymphocyte precursor/bone marrow stromal cell adhesion. The CD49d antigen, when associated with the ß integrin, forms a lymphocyte homing receptor for Peyer's patch, binding tothe mucosal vascular addressin MAdCAM-1. The CD49d antigen is also involved in CD3-dependent CD4+ T-lymphocyte activation via its interaction with fibronectin.
    
    Please contact us at for specific academic pricing.
- Properties
  - Isotype
    
    IgG1
    
    Reactivity
    
    human
    
    Clone
    
    ALC1/1
    
    Immunogen
    
    Tissue / cell preparation (JM leukemia line).
    
    Conjugate
    
    PURE
    
    Concentration
    
    Please refer to the Certificate of Analysis for the lot-specific concentration.
    
    Molecular Weight
    
    150 kDa
    
    Regulatory Status
    
    RUO
    
    Antigen
    
    Alpha-4 integrin chain; VLA-4 alpha chain, CD49 antigen-like family member D, Integrin alpha-IV, VLA-4 subunit alpha (Gene ID:3676)
    
    * For research use only.
- Applications
  - Application
    
    Flow Cytometry
    
    Application Description
    
    CD49b, clone ALC1/1 is a mAb primarily expressed on T and B lymphocytes and weakly expressed on monocytes. This reagent is effective for direct IF staining of human tissue for FCM analysis using ≤1 μg/106 cells.
- Reference
  - https://doi.org/10.1016/j.ab.2014.01.002

Datasheet

MSDS

PURE - anti Human CD49d - ALC1/1

PURE - anti Human CD49d - ALC1/1

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