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Overview
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Threonine362/Serine363 (T362/S363) is a major phosphorylation site of the Neuropeptide Y Receptor 1. The pT362/pS363-NPY1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T362/S363 phosphorylation is primarily mediated by GRKs and is a key regulator of NPY1 desensitization, β-arrestin recruitment and internalization.
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