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Overview
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Serine360 (S360) is a major phosphorylation site of the TRH1 receptor. The pS360-TRH1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S360 phosphorylation is primarily mediated by GRKs and is a key regulator of TRH1 desensitization, β-arrestin recruitment and internalization.
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