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Overview
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Serine355 (S355) is a major phosphorylation site of the β2 adrenoceptor. The pS355-β2 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S355 phosphorylation is primarily mediated by GRK6 and is a key regulator of β2 desensitization, β-arrestin recruitment and internalization.
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