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Overview
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Serine286/Threonine287/Serine288 is a major phosphorylation site of the M2 Muscarinic Acetylcholine Receptor. The pS286/pT287/pS288-M2 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. S286/T287/S288 phosphorylation is a key regulator of M2 desensitization, β-arrestin recruitment and internalization.
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