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Overview
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Calculated MW: 42kDa
Observed MW: 42kDaPlease contact us at for specific academic pricing.
Background
Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development (By similarity. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha- or lipopolysaccharide (LPS-dependent manner, and hence prostaglandin E2 biosynthesis.
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