Phospho-Syk (Tyr525) Rabbit Polyclonal Antibody

Phospho-Syk (Tyr525) Rabbit Polyclonal Antibody

Catalog Number:
A001452842ZEN
Mfr. No.:
Zen-370387
Price:
  • Size:
    100μl
    Quantity:
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      • Overview
        • Please contact us at for specific academic pricing.

          Background

          Syk (spleen tyrosine kinase) is a 635 amino acid protein that contains one protein kinase domain and two SH2 domains. One of several members of the protein kinase superfamily, Syk functions as a positive effector of B cell antigen receptor (CD79)-stimulated responses, coupling CD79 with the movement of one calcium ion through one of two phospho-regulated pathways. Via its ability to influence CD79 activity and to control the movement of calicum through the cell, Syk plays an important role in a variety of cellular responses, including differentiation, phagocytosis, proliferation and B cell development. Syk expression is upregulated in T cell lymphoma, suggesting a possible role for Syk in tumorigenesis. Two isoforms of Syk, designated short and long, exist due to alternative splicing events.

      • Properties
        • Host
          rabbit
          Isotype
          IgG
          Reactivity
          human; rat
          Immunogen
          Synthetic phosphopeptide derived from human Syk around the phosphorylation site of Tyrosine 525.
          Purification
          Affinity Purified
          Conjugate
          Unconjugated
          Formulation
          1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
          Storage
          Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
          Antigen
          (Gene ID:6850; UniProt:P43405)

          * Research Use Only Product (RUO). Not for Diagnosis or Therapeutic Use.

      • Applications
        • Application
          WB; IHC-P
        • Application Dilutions
          WB 1/500-1/1000
          IHC 1/50-1/200

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