Phospho-ErbB 2 (Tyr1221/Tyr1222) Rabbit Polyclonal Antibody

Phospho-ErbB 2 (Tyr1221/Tyr1222) Rabbit Polyclonal Antibody

Catalog Number:
A001450155ZEN
Mfr. No.:
Zen-341438
Price:
  • Size:
    100μl
    Quantity:
    Add to Cart:
      • Overview
        • Please contact us at for specific academic pricing.

          Background

          This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.

      • Properties
        • Host
          rabbit
          Isotype
          IgG
          Reactivity
          human; mouse; rat
          Immunogen
          The antiserum was produced against synthesized peptide derived from human HER2 around the phosphorylation site of Tyr1221/Tyr1222.
          Purification
          Affinity Chromatography
          Conjugate
          Unconjugated
          Formulation
          Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
          Storage
          Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
          Molecular Weight
          Calculated MW: 138 kDa; Observed MW: 180 kDa
          Antigen
          (Gene ID:2064; UniProt:P04626)

          * Research Use Only Product (RUO). Not for Diagnosis or Therapeutic Use.

      • Applications
        • Application
          WB; IHC-P; IP; ELISA
        • Application Dilutions
          WB 1/500-1/1000
          IHC 1/50-1/100
          IP 1/20
          ELISA 1/10000

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