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Overview
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Calculated MW: 21kDa/27kDa
Observed MW: 26KDaPlease contact us at for specific academic pricing.
Background
Acts as a guanine nucleotide exchange factor (GEF which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity.
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