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Overview
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Calculated MW: 113kDa/115kDa
Observed MW: 115kDaPlease contact us at for specific academic pricing.
Background
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub, but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me and 'Lys-79' (H3K79me and leads to gene activation, including that of HOXA9 and MEIS1.
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