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Overview
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Calculated MW: 46kDa/60kDa/61kDa/63kDa/64kDa/66kDa
Observed MW: Refer to figuresPlease contact us at for specific academic pricing.
Background
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.
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