Name: Mifepristone
Price: 188.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Mifepristone (RU486) is a potent antagonist of progesterone receptor, used as a contraceptive agent [1].
    As a contraceptive agent, Mifepristone has been reported to reduce the size of uterine fibroids, and inhibit the growth of meningioma cells in vitro, in experimental animal models and in patients with inoperable meningiomas. As a non-contraceptive action, Mifepristone was been revealed to inhibit the proliferation of normal and malignant endometrial cells, breast cancer cells, prostate cancer cells and gastric adenocarcinoma cell lines. In addition, Mifepristone has been demonstrated to have progesterone-like effects and suppression ovarian cancer cell growth in a dose-dependent fashion with the IC50 values of 6.25μmol/l and 6.91μmol/l for SK-OV-3 and OV2008 cell lines, respectively [1].
    
    [1] Goyeneche AA1, Carón RW, Telleria CM. Mifepristone inhibits ovarian cancer cell growth in vitro and in vivo. Clin Cancer Res. 2007 Jun 1; 13(11):3370-9.
- Properties
  - Categories
    
    Progesterone receptor antagonist
    
    Alternative Name
    
    (8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
    
    CAS Number
    
    84371-65-3
    
    Molecular Formula
    
    C29H35NO2
    
    Molecular Weight
    
    429.59
    
    Appearance
    
    A solid
    
    Purity
    
    99.21%
    
    Solubility
    
    ≥21.48 mg/mL in DMSO; insoluble in H2O; ≥21.45 mg/mL in EtOH with gentle warming
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC#CC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)O
    
    * For Research Use Only
- Reference
  - 1. Sarah D. Burnett, Alexander D. Blanchette, et al. "Cardiotoxicity Hazard and Risk Characterization of ToxCast Chemicals Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Multiple Donors." Chem Res Toxicol. 2021 Sep 20;34(9):2110-2124. PMID:34448577
    2. Xiongjuan Li, Weihong Wang, et al. "Antinociceptive effects of IL-6R vs. glucocorticoid receptors during rat hind paw inflammatory pain." Neuroscience Letters Volume 738, 1 November 2020, 135356. PMID:32898615
    3. Horchar M, Wohleb ES. "Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress." Brain Behav Immun. 2019 Jun 27. pii: S0889-1591(19)30167-9. PMID:31255679
    4. Martin LF, Richardson LS, et al. "Dexamethasone induces primary amnion epithelial cell senescence through telomere-P21 associated pathway†." Biol Reprod. 2019 Jun 1;100(6):1605-1616. PMID:30927408
    5. Li Q, Deng Q, et al. "Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses." Nat Commun. 2018 Sep 6;9(1):3600. PMID:30190514
    6. Shewade LH, Schneider KA, et al. "In-vivo regulation of Krüppel-like factor 9 by corticosteroids and their receptors across tissues in tadpoles of Xenopus tropicalis. "Gen Comp Endocrinol. 2017 Feb 20. pii: S0016-6480(16)30412-9. PMID:28232027