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Overview
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LIN28B belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.
PRODUCT INFORMATION
Antigen Species: Human
NCBI Accession No: NP_001004317.1
RNA Reference Number: NM_001004317.3
OMIM Number: 611044
Chromosome Location: 6q21
cDNA size: 753bpPlease contact us at for specific academic pricing.
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