Name: Jasplakinolide
Price: 420.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Jasplakinolide, a cyclodepsipeptide originally isolated from the marine sponge, Jaspis johnstoni, is a potent inducer of actin polymerization, which also stabilizes pre-formed actin filaments. Jasplakinolide may exert its cytotoxic effect by binding to F-actin. Compared with Ca2+-actin, jasplakinolide shows a much greater effect on Mg2+-actin, and binds to F-actin competitively with phalloidin with a Kd value of ~ 15 nM. Jasplakinolide exhibits both fungicidal and antiproliferative activity. In addition, jasplakinolide is membrane-permeable, which makes it a commonly used tool in cell biology, when actin polymerization or actin filament stabilization has to be achieved.
    
    1. Bubb MR, Senderowicz AM, Sausville EA, et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. Journal of Biological Chemistry, 1994, 269(21): 14869-14871.
    2. Holzinger A. Jasplakinolide: an actin-specific reagent that promotes actin polymerization. Methods in Molecular Biology, 2009, 586: 71-87.
- Properties
  - Categories
    
    A potent actin polymerization inducer, which also stabilizes pre-existing actin filaments
    
    Alternative Name
    
    (4R,7R,10S,13R,17R,19S,E)-7-((2-bromo-1H-indol-3-yl)methyl)-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetraone
    
    CAS Number
    
    102396-24-7
    
    Molecular Formula
    
    C36H45BrN4O6
    
    Molecular Weight
    
    709.67
    
    Appearance
    
    An off-white solid
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    BrC(NC1=CC=CC=C21)=C2C[[email protected]](C(N[[email protected]@H](C(C=C3)=CC=C3O)CC(O[[email protected]@H](C)C[[email protected]@H](C)C=C(C)C[[email protected]@H](C)C(N[[email protected]]4C)=O)=O)=O)N(C)C4=O
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Jasplakinolide

Jasplakinolide

Background

Documents

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