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Overview
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Gene Accession: NP002195
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Background
ITGA3,also named as MSK18,CD49c,GAPB3 and FRP-2,belongs to the integrin alpha chain family. It is a receptor for fibronectin,laminin,collagen,epiligrin,thrombospondin and CSPG4. ITGA3 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. ITGA3 is highly concentrated in epithelial cells where it strongly adheres to Laminin-5 and Laminin-5 induced rapid adhesion can be blocked by antibodies against the alpha-3 integrin subunit. It can be cleaved into heavy chain(840aa) and light chain(176aa). This antibody can recognize the heavy chain.
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