Human UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4) CLIA Kit

E3 Ubiquitin-Protein Ligase Ubr4; 600 Kda Retinoblastoma Protein-Associated Factor; N-Recognin-4; Ring-Type E3 Ubiquitin Transferase Ubr4; Retinoblastoma-Associated Factor Of 600 Kda; Rbaf600; P600; Zinc Finger Ubr1-Type Protein 1

UBR4_HUMAN ; Reactome: R-HSA-6798695 ; Gene ID: 23352

Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.