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Target Information
Target NameTumor Necrosis Factor Receptor Superfamily Member 1b; Tumor Necrosis Factor Receptor 2; Tnf-R2; Tumor Necrosis Factor Receptor Type Ii; Tnf-Rii; Tnfr-Ii; P75; P80 Tnf-Alpha Receptor; Cd Antigen Cd120b; Etanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2; Tbp-2; TbpiiDatabase LinksTNR1B_HUMAN ; Reactome: R-HSA-5668541 ; Gene ID: 7133About TargetFunction: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
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