Human STMN1 (Stathmin 1) CLIA Kit

Stathmin; Leukemia-Associated Phosphoprotein P18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein P19; Pp19; Prosolin; Protein Pr22; Pp17

STMN1_HUMAN ; Reactome: R-HSA-1251985 ; Gene ID: 3925

Tissue Specificity: Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

Function: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.