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Overview
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This SIGLEC8 CLIA Kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.
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Target Information
Target NameSialic Acid-Binding Ig-Like Lectin 8; Siglec-8; Sialoadhesin Family Member 2; Saf-2Database LinksSIGL8_HUMAN ; Reactome: R-HSA-198933 ; Gene ID: 27181About TargetTissue Specificity: Expressed specifically on red blood cells namely basophil, mast cells and eosinophils.
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes.
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