Human PTGIS (Prostaglandin I Synthase) CLIA Kit

Prostacyclin Synthase; Hydroperoxy Icosatetraenoate Dehydratase; Prostaglandin I2 Synthase

PTGIS_HUMAN ; Reactome: R-HSA-193368 ; Gene ID: 5740

Tissue Specificity: Widely expressed.particularly abundant in ovary, heart, skeletal muscle, lung and prostate.

Function: Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation. Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE).