Human MRC2 (Mannose Receptor C Type 2) CLIA Kit

C-Type Mannose Receptor 2; C-Type Lectin Domain Family 13 Member E; Endocytic Receptor 180; Macrophage Mannose Receptor 2; Urokinase-Type Plasminogen Activator Receptor-Associated Protein; Upar-Associated Protein; Urokinase Receptor-Associated Protein; Cd Antigen Cd280

MRC2_HUMAN ; Reactome: R-HSA-1236978 ; Gene ID: 9902

Tissue Specificity: Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.

Function: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).