Human KNG1 (Kininogen 1) CLIA Kit

Kininogen-1; Alpha-2-Thiol Proteinase Inhibitor; Fitzgerald Factor; High Molecular Weight Kininogen; Hmwk; Williams-Fitzgerald-Flaujeac Factor Cleaved Into - Kininogen-1 Heavy Chain - T-Kinin; Ile-Ser-Bradykinin - Bradykinin; Kallidin I - Lysyl-Bradykinin; Kallidin Ii - Kininogen-1 Light Chain - Low Molecular Weight Growth-Promoting Factor

KNG1_HUMAN ; Reactome: R-HSA-114608 ; Gene ID: 3827

Tissue Specificity: Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.

Function: (1) Kininogens are inhibitors of thiol proteases.(2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII.(3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes.(4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action).(5) LMW-kininogen inhibits the aggregation of thrombocytes.(6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.