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Overview
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Human IL-36-gamma Recombinant Protein (Animal Free) Lyophilized from Innovative Research has been recombinantly produced in E. coli. This is a Lyophilized protein buffered in with a purity of ? 95% by SDS-PAGE gel and HPLC analyses.
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Background
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 ? (IL-1F6), ? (IL-1F8) and ? (IL-1F9). IL-36? is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36? signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36? also functions as an agonist of NF-?B, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant Human IL-36? is a 17.0 kDa protein containing 152 amino acid residues.
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- Properties
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Overview