Name: Human HTRA2/OMI (S306A) antibody
Price: 544.00 USD

- Overview
  - Please contact us at for specific academic pricing.
- Properties
  - Host
    
    mouse
    
    Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG1 kappa
    
    Reactivity
    
    human
    
    Clone
    
    1B3
    
    Immunogen
    
    Recombinant human HtrA2/Omi (134-458aa) purified from E. coli
    
    Purification
    
    By protein-G affinity chromatography
    
    Formulation
    
    Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
    
    Storage
    
    Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.
    
    Concentration
    
    1mg/ml (determined by BCA assay)
    
    Antigen
    
    HtrA serine peptidase 2, High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, PRSS25, OMI, PARK13 (UniProt:O43464)
    
    * For research use only. Not intended for human, diagnostics or veterinary use.
- Applications
  - Application
    
    ELISA; WB
    
    Application Description
    
    The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
- Reference
  - Kim GY, et al. A simple and rapid strategy for the molecular cloning and monitoring of mouse HtrA2 serine protease. (Biotechnol Lett. 2008)
    Park HJ, et al. Intracellular Abeta and C99 aggregates induce mitochondria-dependent cell death in human neuroglioma H4 cells through recruitment of the 20S proteasome subunits. (Brain Res. 2009)
    Shin EJ, et al. Matrix metalloproteinase-3 is activated by HtrA2/Omi in dopaminergic cells: relevance to Parkinsons disease. (Neurochem Int. 2012)
    Goo HG, et al. HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA. (Biochim Biophys Acta. 2013)
    Goo HG, et al. HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis. (Exp Cell Res. 2014)
    Nam MK, et al. HtrA2 regulates α-Synuclein-mediated mitochondrial reactive oxygen species production in the mitochondria of microglia. (Biochem Biophys Res Commun. 2023)

Human HTRA2/OMI (S306A) antibody

Human HTRA2/OMI (S306A) antibody

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