Human GPR37 (G Protein Coupled Receptor 37) CLIA Kit

Prosaposin Receptor Gpr37; Endothelin B Receptor-Like Protein 1; Etbr-Lp-1; G-Protein Coupled Receptor 37; Parkin-Associated Endothelin Receptor-Like Receptor; Paelr

GPR37_HUMAN ; Reactome: R-HSA-375276 ; Gene ID: 2861

Tissue Specificity: Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ).

Function: Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.