Human GLRX3 (Glutaredoxin 3) CLIA Kit

Glutaredoxin-3; Pkc-Interacting Cousin Of Thioredoxin; Picot; Pkc-Theta-Interacting Protein; Pkcq-Interacting Protein; Thioredoxin-Like Protein 2

GLRX3_HUMAN ; Reactome: R-HSA-917937 ; Gene ID: 10539

Tissue Specificity: Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.

Function: Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates 2Fe-2S cluster insertion into a subset of cytosolic proteins. Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.