Human FPR2 (Formyl Peptide Receptor 2) CLIA Kit

N-Formyl Peptide Receptor 2; Fmlp-Related Receptor I; Fmlp-R-I; Formyl Peptide Receptor-Like 1; Hm63; Lipoxin A4 Receptor; Lxa4 Receptor; Rfp

Uniprot ID: PRL_RAT ; Reactome: R-HSA-416476 ; Gene ID: 2358

Tissue Specificity: Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.

Function: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation.