Human FABP6 (Fatty Acid Binding Protein 6, Ileal) CLIA Kit

Gastrotropin; Gt; Fatty Acid-Binding Protein 6; Ileal Lipid-Binding Protein; Ilbp; Intestinal 15 Kda Protein; I-15p; Intestinal Bile Acid-Binding Protein; I-Babp

Uniprot ID: TLR9_HUMAN ; Reactome: R-HSA-159418 ; Gene ID: 2172

Tissue Specificity: Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is xpressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level).

Function: Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion. Isoform 2: Essential for the survival of colon cancer cells to bile acid-induced apoptosis.