Human CTLA4 (Cytotoxic T Lymphocyte Associated Antigen 4) CLIA Kit

Cytotoxic T-Lymphocyte Protein 4; Cytotoxic T-Lymphocyte-Associated Antigen 4; Ctla-4; Cd Antigen Cd152

Uniprot ID: PROZ_HUMAN ; Reactome: R-HSA-389513 ; Gene ID: 1493

Tissue Specificity: Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.

Function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.