Human CD86 (T-Lymphocyte Activation Antigen CD86) CLIA Kit

T-Lymphocyte Activation Antigen Cd86; Activation B7-2 Antigen; B70; Bu63; Ctla-4 Counter-Receptor B7.2; Fun-1; Cd Antigen Cd86

Uniprot ID: MRC2_HUMAN ; Reactome: R-HSA-1257604 ; Gene ID: 942

Tissue Specificity: Expressed by activated B-lymphocytes and monocytes.

Function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. Isoform 2: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B.