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Overview
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This CASP7 CLIA Kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.
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Target Information
Target NameCaspase-7; Casp-7; Apoptotic Protease Mch-3; Cmh-1; Ice-Like Apoptotic Protease 3; Ice-Lap3 Cleaved Into - Caspase-7 Subunit P20 - Caspase-7 Subunit P11Database LinksUniprot ID: LCN1_HUMAN ; Reactome: R-HSA-111459 ; Gene ID: 840About TargetTissue Specificity: Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
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