Name: Human Bone Morphogenetic Protein-2
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- Overview
  - Predicted MW: Dimer, 13.0/26.1 kDa (115/230 aa). Bone morphogenetic protein 2 (BMP-2) is a member of the bone morphogenetic protein (BMP) family and functions as a potent inducer of bone and cartilage development. BMP proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. Active BMP-2 consists of forming a homodimer or a heterodimer with a related BMP, such as BMP-7. BMP-2 signals through type I and type II receptor tyrosine kinases in conjuction with SMAD proteins to directly promote osteoblast differentiation. BMP-2 is also important during cardiac development and supports epicardial cell migration.
    
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- Properties
  - Protein Name
    
    BMP-2A, BMP2A
    
    Source
    
    Genetically modified E.coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Reducing and Non-Reducing SDS PAGE at >= 95%
    
    Formulation
    
    Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
    Sterile water at 0.1 mg/mL
    
    Storage
    
    Store at -20°C
    
    Endotoxin
    
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
    
    Activity
    
    Biological Activity was determined by Alkaline phosphatase activity induced in ATDC-5 cells at <= 250 ng/mL; >= 4.0 x 10^3 units/mg. Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.
    
    More Information
    
    UniProt
    
    P12643
    
    Gene ID
    
    650
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Human Bone Morphogenetic Protein-2

Human Bone Morphogenetic Protein-2

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