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Overview
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This BAK1 CLIA Kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.
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Target Information
Target NameBcl-2 Homologous Antagonist/Killer; Apoptosis Regulator Bak; Bcl-2-Like Protein 7; Bcl2-L-7Database LinksUniprot ID: LGUL_HUMAN ; Reactome: R-HSA-111452 ; Gene ID: 578About TargetTissue Specificity: Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
Function: Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.
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