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Overview
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HNRNPAB Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 308 amino acids (1-285 a.a) and having a molecular mass of 33kDa. HNRNPAB is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Heterogeneous Nuclear Ribonucleoprotein A/B(HNRNPAB) is a member of the subfamily of ubiquitously expressed heterogeneousnuclear ribonucleoproteins(hnRNPs). The hnRNPs are produced by RNA polymerase II and are components oftheheterogeneous nuclear RNA (hnRNA) complexes. They are linked with pre-mRNAsin the nucleus and seem to influence pre-mRNA processing and further aspects ofmRNA metabolism and transport. Whereas all of the hnRNPs are present in the nucleus, some seem toshuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinctnucleic acid binding properties. HNRNPAB, which binds to one of the componentsof the multiprotein editosomecomplex, has two repeats of quasi-RRM (RNA recognition motif) domains that bindto RNAs. Among the diseases associated with HNRNPABare wells syndrome, and cystic fibrosis.
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Overview