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Overview
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HMGN3 Human Recombinant produced in E. Coli is a single,non-glycosylated polypeptide chain containing 100 amino acids (1-77 a.a) andhaving a molecular mass of 10.8 kDa. HMGN3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. High Mobility Group Nucleosomal Binding Domain 3 (HMGN3), binds thyroidhormone receptor beta, however it occurs only in the presence of thyroidhormone. Thyroid hormone receptors are hormone-dependent transcription factorswhich regulate expression of a variety of particular target genes. HMGN3 is considered to reduce the compactnessof the chromatin fiber in nucleosomes, in that way enhancing transcription fromchromatin templates.
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Overview