GT3-Oligosaccharide

GT3-Oligosaccharide

Catalog Number:
C003140514BIO
Mfr. No.:
OO46229
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      • Overview
        • GT3 oligosaccharide (free acid) is a disaccharide (Galβ1,4Glc) with three sialic acid residues (NeuAc) linked α2,8/α2,8/α2,3 to the galactose residue (Ledeen, 2009). The GT3 ganglioside is the carbohydrate moiety in the GT3 ganglioside, which is implicated in type 1 diabetes. GT3 ganglioside is expressed on pancreatic cells and is the target antigen of anti-GM3-antibodies, which contribute to the autoimmune destruction of pancreatic beta cells (Misasi, 1997). GT3 ganglioside is also abundant in lung tissues and the nervous system.

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      • Properties
        • Categories
          Ganglioside Oligosaccharides and Gangliosides
          Alternative Name
          Neu5Aca2-8Neu5Aca2-8Neu5Aca2-3Galb1-4Glc
          Molecular Formula
          C45H70N3O35Na3
          Molecular Weight
          1,282.01 g/mol
          Note
          There is no hazardous surcharge associated with this product.
          There is no special packaging charge associated with this product.

          * For research use only. Not for human or veterinary use

      • Reference
        • Ledeen et al (2009) Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J), pp 495-516, Wiley-VCH, Weinheim
          Misasi et al (1997) Gangliosides and autoimmune diabetes, Diabetes/metabolism Reviews, 13(3), 163-179.

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