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GT1b-Ganglioside ammonium

GT1b-Ganglioside ammonium

Catalog Number:
C003141132BIO
Mfr. No.:
OG167138
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      • Overview

        • GT1b ganglioside (ammonium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, sialic acid (NeuAc) linked α2,3 to the terminal galactose residue, and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GT1b ganglioside is one of the major gangliosides in neuronal and glial membranes. It interacts with myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. GT1b ganglioside also acts as a receptor for bacterial toxins, such as, tetanus and botulinum toxins (Nishiki, 1996), as well as for viruses. A few examples of which include: Merkel cell polyomavirus, JC virus, BK virus, norovirus, and others (Low, 2006).

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      • Properties
        • Categories
          Ganglioside Oligosaccharides and Gangliosides
          CAS Number
          59247-13-1
          Molecular Formula
          C95H165N5O48·xNH4
          Molecular Weight
          2,145.33 g/mol
          MDL Number
          MFCD00081622
          Note
          There is no hazardous surcharge associated with this product.
          There is no special packaging charge associated with this product.

          * For research use only. Not for human or veterinary use

      • Reference

        • Ledeen et al (2009) Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J), pp 495-516, Wiley-VCH, Weinheim
          Nishiki et al (1996) The high‐affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a, Febs Letters, 378(3), 253-257
          Low et al (2006) Identification of Gangliosides GD1b and GT1b as Receptors for BK Virus, Journal of Virology, 80(3), 1361-1366

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