GSPure® RNase R

RNase R (Ribonuclease R) is a 3'-5' exonuclease derived from the Escherichia coli RNR superfamily that progressively cuts RNA into dinucleotides and trinucleotides from the 3'-5' direction. RNase R can digest almost all linear RNA molecules, but it is difficult to digest circular RNA, lasso structures, or double-stranded RNA molecules with fewer than seven nucleotides at the 3' protruding end.
RNase R is an essential tool enzyme for circRNA identification and enrichment experiments, digesting linear RNA to enrich for circular RNAs (circRNAs) or lasso-structured RNAs (lariat RNAs).

Advantages
High specificity: specific digestion of linear RNA;
Highly efficient: most linear RNA can be digested in 5-15min;
Buffer compatible: the digested product can be directly used in downstream experiments;
Easy to use: simple system, one-step reaction at 37°C.

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