GPR109A/HM74A/HCAR2 Polyclonal Antibody

GPR109A/HM74A/HCAR2 Polyclonal Antibody

Catalog Number:
A001511783RED
Mfr. No.:
RD90146A
Price:
$416
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      • Overview
        • Calculated MW: 99kDa
          Observed MW: 102KDa

          Please contact us at for specific academic pricing.

          Background

          Acts as a high affinity receptor for both nicotinic acid (also known as niacin and (D-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.

      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; mouse; rat
          Immunogen
          A synthetic peptide of human GPR109A/HM74A/HCAR2
          Purification
          Affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.05% proclin300,50% glycerol,pH7.3.
          Storage
          Store at -20°C Valid for 12 months. Avoid freeze-thaw cycles.
          Concentration
          1mg/mL
          Antigen
          HCAR2, GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g (Gene ID:338442; UniProt:Q8TDS4)

          * For reference only.

      • Applications
        • Application
          WB; IHC
        • Application Dilutions
          WB 1:500-1:2000
          IHC 1:50-1:200

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