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GM1-Pentasaccharide labelled by biotin

GM1-Pentasaccharide labelled by biotin

Catalog Number:
C003143517BIO
Mfr. No.:
OP31185
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      • Overview

        • GM1 pentasaccharide biotin (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue and biotin linked β to position 1 on the reducing glucose moiety (Ledeen, 2009). The parent ganglioside GM1 is abundant in all mammalian brains, where it covers 10%-20% of the total ganglioside mixture. It is found in epithelial membranes and is a key element for bacterial toxicity and viral infection as it is the intestinal receptor for cholera toxin the B-subunits of heat-labile toxin, rotavirus, and simian virus 40. GM1 ganglioside functions as a neurotrophic and neuroprotective compound and has been used therapeutically for diabetic and peripheral neuropathies. GM1 ganglioside also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).

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      • Properties
        • Categories
          Ganglioside Oligosaccharides and Gangliosides
          Alternative Name
          GM1-Pentasaccharide-O(CH2)3NHCO(CH2)5NH-biotin
          Molecular Formula
          C50H83N5O31S
          Molecular Weight
          1,282.28 g/mol
          Note
          There is no hazardous surcharge associated with this product.
          There is no special packaging charge associated with this product.

          * For research use only. Not for human or veterinary use

      • Reference

        • Ledeen et al (2009) Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J) pp 495-516, Wiley-VCH, Weinheim
          Chiricozzi et al (2020) GM1 Ganglioside Is A Key Factor in Maintaining the Mammalian Neuronal Functions Avoiding Neurodegeneration, International journal of molecular sciences, 21(3), 868.

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