Name: GM1-Ganglioside labelled by biotin
Price: Inquiry

- Overview
  - GM1-biotin ganglioside (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue, ceramide linked β to position 1 on the reducing terminal glucose residue, and biotin to position 5 on sialic acid (Ledeen, 2009). GM1 ganglioside is abundant in all mammalian brains where it covers 10%-20% of the total ganglioside mixture. It is found in epithelial membranes and is a key element for bacterial toxicity and viral infection as it is the intestinal receptor for the cholera toxin, the B-subunits of heat-labile toxin, rotavirus, and simian virus 40. GM1 ganglioside functions as a neurotrophic and neuroprotective compound, and has been used therapeutically for diabetic and peripheral neuropathies. GM1 ganglioside also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).
    
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- Properties
  - Categories
    
    Ganglioside Oligosaccharides and Gangliosides
    
    Alternative Name
    
    N-Hexanoyl-biotin-monosialoganglioside GM1
    
    Molecular Formula
    
    C71H122N6O33S
    
    Molecular Weight
    
    1,619.82 g/mol
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Ledeen et al (2009), Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J), pp 495-516, Wiley-VCH, Weinheim
    Chiricozzi et al (2020), GM1 Ganglioside Is A Key Factor in Maintaining the Mammalian Neuronal Functions Avoiding Neurodegeneration, International Journal of Molecular Sciences, 21(3), 868.

GM1-Ganglioside labelled by biotin

GM1-Ganglioside labelled by biotin

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