GD2-Oligosaccharide-b-(N-acetyl-propargyl)

The core trisaccharide of the ganglioside GD2,protected with a propargyl glycoside group, is the most prominent alkynyl glycoside used in oligosaccharide synthesis (Das, 2016). The structure (sodium salt) comprises (GalNAcβ1,4Galβ1,4Glc) of its two sialic acids linked α2,3/α2,8 to the central galactose residue (Ledeen, 2009). GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors including neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, GD2 ganglioside has been found in low concentrations on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state) and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).

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