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Overview
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GATC Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 159 amino acids (1-136 a.a) and having a molecular mass of 17.5kDa (Molecular size on SDS-PAGE will appear higher). GATC is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Glutamyl-TRNAAmidotransferase, Subunit C also known as GATC allows the formation of properlycharged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) inthe mitochondria. The reaction occurs in the attendance of glutamine and ATP throughan activated gamma-phospho-Glu-tRNA(Gln). In addition, GATC is subunit of theheterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (PET112)and C (GATC) subunits.
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- Properties
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Overview