Name: GAD1 iso1 Recombinant Protein
Price: Inquiry

- Overview
  - GAD1 iso1 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 617 amino acids (1-594 a.a) and having a molecular mass of 69.3kDa. GAD1 iso1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Glutamate Decarboxylase 1 Isoform-1, also known as GAD1 iso1 belongs to the group II decarboxylase family. GAD1 iso1 encodes one of several forms of glutamic acid decarboxylase, and is identified as a major autoantigen ininsulin-dependent diabetes. GAD1 iso1 is in charge for catalyzing theproduction of gamma-aminobutyric acid from L-glutamic acid. In addition, apathogenic function for GAD1 iso1 has been shown in the human pancreas while it has been identified as an autoantigen & an autoreactive T cell target ininsulin-dependent diabetes. GAD1 iso1 play a role in the stiff man syndrome. It has been shown that deficiency in this enzyme has led to pyridoxine dependency with seizures.
    
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- Properties
  - Protein Name
    
    Glutamate Decarboxylase 1 (Brain, 67kDa), GlutamateDecarboxylase 67 KDa Isoform, 67 KDa Glutamic Acid Decarboxylase, EC 4.1.1.15, GAD-67, CPSQ1, SCP, GAD, Glutamate Decarboxylase 1 (Brain, 67kD), GlutamateDecarboxylase 1, EC 4.1.1, GAD67, Glutamate
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 80% as determined by SDS-PAGE.
    
    Formulation
    
    GAD1 iso1 protein solution (0.5 mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

GAD1 iso1 Recombinant Protein

GAD1 iso1 Recombinant Protein

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